can T cell immunotherapy work in osteosarcoma and nb?
Project Title: Activated T Cells Armed With GD2 Bispecific Antibody in Children and Young Adults With Neuroblastoma and Osteosarcomas
Researcher: Lawrence Lum, PhD
Institution: Karemanos Cancer Center; Memorial Sloan-Kettering Cancer Center
Study Type: Phase 1 Clinical Trial
Status: Opening in 2015
Summary: This trial studies the side effects and best dose of activated T cells armed with GD2 bispecific antibody and how well they work in treating patients with neurblastoma, osteosarcoma, and other GD2+ solid tumors.
Impact: This study will provide new information on whether infusions of these activated T cells will not only kill the tumor but also "vaccinate" the patients against their own cancer resulting in significant improvement in survival for patients with relapsed GD2-positive tumors.