2023 Year-in-Review

Pediatric Cancer Research Advancements: Solving Kids’ Cancer’s Year-in-Review

A Message from Scott Kennedy, Executive Director

 

Dear Friends and Supporters, 

As we reflect on the year gone by, my heart is filled with gratitude and pride for what we’ve achieved together in 2023. I want to start by extending a heartfelt thank you to each one of our donors, volunteers, collaborators, and families who stand with us in our relentless fight against childhood cancer.

As a pediatric cancer charity focused on funding clinical trials for the most high-risk and fatal childhood cancers, your contributions have been instrumental in securing vital childhood cancer research funding — allowing us to spearhead and accelerate groundbreaking treatments. Just as my son Hazen dreamed of creating new medicines to help others, we’ve not only dreamed, but also transformed those dreams into tangible hope for countless families. 

Big Leaps in Pediatric Cancer Research

2023 was a pivotal year for pediatric cancer research, and Solving Kids’ Cancer was at the forefront:

A purple icon of a person jumping in the air with their arms outstretched.

• Brain Tumor Breakthroughs: Together with top New York City universities, we launched a novel project to tackle high-risk childhood brain tumors using advanced drug delivery methods.

• More Hope through MiniVan: Our transatlantic MiNivAn trial expanded, offering innovative combination immunotherapy to more children with high-risk neuroblastoma.

• Firsts in ETMR Trials: We achieved a landmark with the first approved trial protocol for kids with ETMR brain tumors, involving multiple international centers.

• Advancing Neuroblastoma Research: We led the funding of an innovative trial to quickly enroll kids with a distinct neuroblastoma mutation, initiating a targeted therapy approach.

A group of people are standing around a globe.

Leadership in Global Teamwork 

• PBTRN: A New Era of Collaboration: Our launch of the Pediatric Brain Tumor Research Network (PBTRN) initiated a groundbreaking alliance among NYC cancer centers to enhance research cooperation.

• Push for Data Sharing: We led a pioneering advocacy for open-access critical biomarker data, aiming to refine treatment paths for neuroblastoma globally.

• Influencing Statewide Strategies: We played a key role in shaping the pediatric segment of New York State’s upcoming Cancer Control Plan,1 including priorities for pediatric cancer research funding.

• Global Dialogue at Neuroblastoma Symposium: Our global symposium forged a vital knowledge-sharing space for parents, experts, and caregivers.

A light bulb is sitting on a piece of paper next to a magnifying glass.

Our Research in the Spotlight 

• Challenges of Childhood Cancer: A research paper authored by SKC received critical acclaim and was featured in a New York Times article, shedding light on the unique challenges faced in childhood cancer.

• Advocacy in Pediatric Cancer Research: Our scientific publication in the Journal of Clinical Oncology underscored the indispensable role of advocacy groups like SKC in the pediatric cancer research landscape.

• Prioritizing Life-Saving Drugs: An SKC co-authored research paper made influential recommendations for a class of drugs known as DNA damage response inhibitors, outlining strategies for their impactful investigation in clinical research for children.

• Celebrating Long-Term Success: Our childhood cancer research funding investments and advocacy from 2007 and 2008 led to positive clinical trial results for one treatment option and a potential FDA approval for another in 2023.

A group of people are sitting around a heart.

Events That Brought Us Together

• Spring Celebration Gala: Our annual gala was a resounding success, uniting supporters and raising critical funds for ongoing pediatric cancer research.

• Summer Luncheon: This sold-out event rallied support from Long Island communities, celebrating SKC’s milestones and looking ahead to future endeavors.

• Whiskey for a Cause: Our unique whiskey tasting event at Edrington Spirits headquarters served as a beautiful backdrop for sharing SKC’s journey, fostering new connections, and solidifying support for our cause.

We’ve made great strides this year in pediatric cancer research, but our work is far from complete. Your support is the driving force behind advancing new research and treatments that could save children’s lives.


How you can make an impact this holiday season

• Create Your Own Fundraiser: Using our easy-to-use platform, personalize your campaign and turn your passions into action for kids with cancer.

• Spread the Word on Social Media: Help raise awareness by sharing our mission and updates on your networks. You can find and tag us on Facebook and Instagram.

• Make a Tax-Deductible Donation: Every contribution, big or small, helps us get one step closer to our goal of increasing childhood cancer research funding.

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From everyone at Solving Kids’ Cancer, thank you for your generosity and for believing in a future where every kid has the chance to grow up. 

With deep gratitude,

A black and white signature of scott on a white background.

Scott Kennedy

Executive Director & Co-Founder

Solving Kids’ Cancer

Sources
1 New York State Comprehensive Cancer Control Plan 2018-2023 – https://www.nyscancerconsortium.org/img/uploads/file/2018-2023%20NYS%20Comprehensive%20Cancer%20Control%20Plan.pdf
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Ahana’s Story of Strength with High-Risk Neuroblastoma Every day, over 1,000 children worldwide are diagnosed with cancer,1 and for many families, that diagnosis means facing an uncertain future. At just 20 months old, Ahana was diagnosed with a rare and aggressive cancer that had already spread through her small body. Her family’s search for life-saving childhood cancer treatments led them from South Africa to Spain and possibly toward a clinical trial in New York. Ahana’s journey shows the importance of supporting organizations like Solving Kids’ Cancer, which works to find, fund, and advocate for advanced treatments that give hope to families fighting against tough-to-treat rare pediatric cancers.
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November 11, 2024
Advancing Childhood Cancer Research: SKC’s 2024 Milestones
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October 1, 2024
Lace Up for Kids: Your Impact on Childhood Cancer Research At Solving Kids’ Cancer, our mission has always been driven by hope — hope for better treatments, hope for breakthroughs, and most importantly, hope for every child fighting cancer. This year’s Lace Up for Kids campaign was nothing short of inspiring. Together, we’ve raised over $264,000 across the entire campaign, funding innovative childhood cancer research and providing more treatment options for children in need.  From coast to coast, nearly 4,000 participants have stepped up to lace up their gold shoelaces and make a difference. Whether it was through schools, sports teams, or community groups, the show of support has been overwhelming throughout the years. Over 7,823 donations have been made to accelerate new treatments, and the hashtag #CareWearShare has been used 13,864 times, spreading the message far and wide!
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September 2, 2024
Gold Laces for Childhood Cancer Awareness Month: Erin’s Story 
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August 8, 2024
Smithtown Goes Gold for Childhood Cancer Awareness Month!
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August 6, 2024
Childhood Cancer Awareness Month: Lace Up for Kids 2024
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August 1, 2024
Osteosarcoma Survivor to Surgeon: Dr. Kurt Weiss’ Story
Jacob 's journey : a childhood cancer survivor 's story
May 10, 2024
Jacob’s Journey: A Childhood Cancer Survivor’s Story Every battle has its heroes, and among the bravest are young children like Jacob Mozer, who faced stage 4 high-risk neuroblastoma when he was barely old enough to walk. Diagnosed at only 16 months old, Jacob’s early years were filled with constant medical appointments and intense treatments. Despite these challenges, today, Jacob is a shining example of the remarkable progress in pediatric oncology. He’s not merely surviving; he’s thriving as a pharmacy resident, driven to give back to the medical community that gave him a second chance at life. During National Cancer Survivors Month this June, we honor and celebrate fighters like Jacob who have battled cancer and emerged stronger. This month also serves to amplify the conversation about pediatric cancer survivorship and push for vital research that continues to save lives. Solving Kids’ Cancer (SKC) plays an essential role in this effort, supporting children like Jacob by funding crucial clinical trials that enhance survival rates and improve the quality of life for those fighting fatal childhood cancers.
A close up of a person holding a test tube in a laboratory.
May 2, 2024
Trailblazing Treatments for Pediatric Brain Tumors Picture a fortress built to guard precious treasure but accidentally also keeps out the very allies it needs in a time of crisis. This is the challenge faced by medical researchers when dealing with the brain’s natural defense — the blood-brain barrier — especially in children with brain tumors. At Columbia University Medical Center, Dr. Luca Szalontay is leading the charge to breach this fortress with groundbreaking approaches. Recently, Dr. Timothy Cripe from Solving Kids’ Cancer’s podcast, This Week in Pediatric Oncology (TWIPO) , interviewed Dr. Szalontay to delve deeper into these innovative treatments. This Brain Tumor Awareness Month, we’re shining a light on these important advances in treating children’s cancer. Understanding the Challenge Treating pediatric brain tumors like diffuse midline glioma (DMG) is especially tough because of the brain’s own protective shield, known as the blood-brain barrier. This barrier keeps out most chemotherapy drugs as well as large molecules, like antibodies, making it hard to treat the tumors effectively. Dr. Szalontay describes the dilemma: “Our field hasn’t been able to advance as quickly as it has with leukemias or other solid tumors because the drugs don’t penetrate the brain efficiently.” She adds on the nature of this blood-brain barrier, “It’s evolutionary, very important to protect us from different toxins and harmful agents, but this is a shield which protects the tumor as well.” Even when drugs work well in lab tests, they struggle to get to the tumor in strong enough doses without harming the body. Dr. Szalontay also points out that DMG tumors are found in very sensitive areas of the brain, making traditional surgery or radiation risky because they could damage vital brain functions. This makes finding safe and effective treatments for these tumors even more challenging. So, what’s being done to tackle these obstacles and help kids fight these tumors?
A group of stick figures are holding hands around a globe.
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World Health Day: Pediatric Cancer’s Global Divide Imagine this: Two children, born at the same moment, oceans apart. In a country brimming with medical resources, one child quickly gets top-notch treatment for cancer. Meanwhile, across the globe, the other child faces a drastically different reality, with limited access to basic care. This isn’t just a thought experiment — it’s the harsh truth of pediatric cancer treatment worldwide. Observed every year on April 7, World Health Day shines a light on the mission to make healthcare accessible for all. This day is particularly significant in the context of pediatric cancer, where vast disparities in treatment availability highlight the global challenge of ensuring every child has the opportunity for health and healing. The Stark Contrast in Survival Rates: A Look at Pediatric Cancer Statistics Every day, more than 1,000 children are diagnosed with cancer, and the chances of survival vary greatly depending on where they live.1 Pediatric cancer survival rates serve as a clear indicator of the disparities between high-income countries (HICs) and low- and middle-income countries (LMICs). In wealthier nations such as the United States and Western Europe, the 5-year survival rate for children with cancer is over 80%, thanks to advanced healthcare systems and access to the latest treatments.2 But, here’s a troubling childhood cancer statistic: in LMICs where 80% of children with cancer live, fewer than 20% survive.1 This gap is due to several factors, including late diagnoses or, tragically, no diagnosis at all. Many children succumb to the disease without access to pain medication, and the burdens of travel and the high costs force most families to abandon care. These challenges are compounded by limited access to necessary treatments,3 as well as a lack of specialized equipment and trained healthcare professionals needed for effective pediatric cancer treatment. Addressing this divide requires a concerted global effort to improve early detection, make treatments more affordable, and enhance healthcare infrastructures, giving every child a fair chance to beat cancer. Navigating the Access Maze Access to cancer care shouldn’t be a treasure hunt. Yet, for many in LMICs, it feels like that — a relentless search for something seemingly out of reach. Here’s the reality revealed in childhood cancer statistics worldwide: many areas lack enough doctors who specialize in children’s cancer4 and the prices of cancer drugs can be sky-high.2 Even getting to a hospital can be an ordeal, with some families traveling hundreds of miles. And the financial strain? Devastating. The cost of care can quickly add up to more than a year’s income, forcing households into deep financial distress. In many LMICs, the lack of comprehensive insurance coverage means families are often left to pay for pediatric cancer treatment entirely out-of-pocket.5 Families often face the impossible choice between their child’s health and their financial survival. Solving Kids’ Cancer: Bridging the Gap Solving Kids’ Cancer (SKC) isn’t standing by; we’re on the front lines, actively working to make a difference in the global pediatric cancer landscape. Beyond funding research, advocating for policy changes, and fostering global partnerships, SKC is committed to educating and empowering the community to take action. We understand that while we might not have a global foothold to address every aspect of the pediatric cancer divide directly, there’s power in collective action. Through our efforts, we aim to catalyze advancements in pediatric cancer treatments and care that could dramatically change outcomes for children worldwide. • Research: We direct funds into cutting-edge studies, searching for breakthrough treatments that promise a brighter future for all kids, regardless of where they live. • Advocacy: We advocate for children’s needs by steering research funding towards unmet challenges and collaborating with experts to prioritize all children, including expanding trials to international sites to maximize access.2 • Global Partnerships: We don’t do it alone. By teaming up with researchers, hospitals, and other organizations across the globe, we’ve helped fund clinical trials that have extended to over 250 institutions across 15 countries worldwide . Uniting for a Cause Solving Kids’ Cancer extends its mission beyond research by fostering community and collaboration. Our signature event, Lace Up for Kids , held annually during September Childhood Cancer Awareness Month, is a powerful testament to this mission, drawing communities together to stand in solidarity against childhood cancer. Additionally, supporters can create their own fundraiser and have a platform to engage their local communities, sparking crucial conversations and garnering support for the cause. These initiatives highlight an important fact: While the challenge of pediatric cancer is significant, each of us has a part to play. By working together and supporting each other, we can fund the research needed to possibly change the direction of pediatric cancer treatment and care worldwide. World Health Day: A Chance for Every Child The fight against pediatric cancer is a stark reminder of the work ahead of us.6 It’s a battle that Solving Kids’ Cancer is dedicated to, but we need more than just our efforts — we need a global movement. This World Health Day, let’s rally for every child’s right to fight cancer on an even playing field. Donate today to help fund more innovative research and one day find a cure for childhood cancer — because every child, no matter where they are born, deserves a chance — a chance to fight, a chance to survive, and a chance to thrive.
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