solving-kids-cancer-143533

Call for Research Grant Proposals: Advancing Medulloblastoma Research

Wed, 14 Jan 2026 16:49:06 GMT

Call For Proposals

Call for Research Grant Proposals: Advancing Medulloblastoma Research

Funding Organizations: The CURE Collaborative (Charities United for Research Excellence)

Bibi Fund, Morgan Adams Foundation, Solving Kids’ Cancer, Ty Louis Foundation

Grant Title: CURE-MB: 2026 Medulloblastoma Breakthrough Catalyst Grants
Letter of Intent (LOI) Deadline: March 1, 2026
Full Proposal Deadline for Invited LOIs: May 1, 2026

Grant Amount: Up to $150,000 per award

Number of Awards: 2

Overview

The CURE Collaborative (Charities United for Research Excellence) invites Letters of Intent for bold, high-risk, high-reward projects that can rapidly advance understanding and treatment of medulloblastoma. We encourage a wide spectrum of proposals that will improve outcomes for medulloblastoma, including those designed to generate pilot/seed data that will position investigators/teams for larger external funding.

Scope of Funding

We welcome proposals that include (but are not limited to):

Biology & mechanisms: molecular, genetic, and epigenetic drivers of medulloblastoma pathogenesis.
Therapeutic innovation: novel targeted agents, immunotherapies, and approaches to personalization/precision medicine.
Translational impact: studies that bridge laboratory discoveries to clear clinical application pathways.

Eligibility Criteria

Researchers worldwide affiliated with accredited academic institutions, hospitals, or research organizations.
Multidisciplinary and collaborative projects are encouraged.
Investigators at all stages of their career are eligible to apply.
Preliminary data is not a pre-requisite.
Clinical trials are not eligible for funding.
Investigators may submit more than one LOI.

Application Process

Interested applicants must submit:

Letter of Intent (max 1 page): objectives/aims, brief methodology, expected outcomes, and a concise innovation paragraph (Times New Roman, 11pt, 1” margins). An additional page of pertinent references is permitted. Please include a separate cover page with proposal title and name of investigator and submit as a single PDF file with the document file labelled with the principal investigator name. LOI should be submitted to grants@solvingkidscancer.org by 11:59 pm ET March 1, 2026
Following LOI review, selected applicants will be invited to submit a full proposal by May 1, 2026.

Evaluation Criteria

Proposals will be evaluated based on the following:

Scientific merit and originality/innovation
Feasibility and methodological rigor
Investigator qualifications and track record
Relevance to medulloblastoma

Potential impact, including but not limited to the likelihood of leveraging larger funding opportunities

Funding and Reporting Requirements

Up to $150,000 total per award, disbursed over 2 years (milestones in 2026 and 2027 ).
Progress and financial reports are required prior to the second-year milestone and at project completion.
Successful projects may be considered for renewal or supplemental funding based on results.
No indirect costs or PI (principal investigator) salary are permitted.

Submission and Contact Information

LOIs must be submitted electronically to grants@solvingkidscancer.org by March 1, 2026 .
Invited full proposals are due May 1, 2026 .
For questions, contact Donna Ludwinski at donna@solvingkidscancer.org

Care For Rare Funding Collaborative

Wed, 10 Sep 2025 18:18:32 GMT

CARE FOR RARE Collaborative Awards $600,000 to Advance Research in Aggressive Childhood Brain Tumors

New York, NY, Oct 1, 2025 – The CARE FOR RARE Collaborative, comprised of six pediatric cancer charities, is announcing $600,000 in funding for rare childhood brain cancers. Three $200,000 grants have been awarded to support research on Embryonal Tumor with Multilayered Rosettes (ETMR) and Atypical Teratoid/Rhabdoid Tumor (ATRT).

The recipients are:

Johannes Gojo, MD, PhD, Professor of Pediatric Neuro-Oncology, Medical University of Vienna, Austria, for “Advanced Resistance Mapping and Overcoming Relapse of ETMR (ARMOR)”
Eric Raabe, MD, PhD, Associate Professor of Pediatric Oncology and Pathology, Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine for “Combined epigenetic targeting in ATRT”
Rajeev Vibhakar, MD, PhD, Professor, Department of Pediatrics, Neuro-Oncology Division, University of Colorado, Denver for “Targeting CDK7 for AT/RT Therapy”

These grants, totaling $600,000, aim to advance discoveries to improve outcomes in these rare and aggressive pediatric brain tumors that affect very young children.

About ETMR and ATRT

ETMR almost exclusively affects children under four years of age and currently has a dismal 5-year survival rate of just 10–30%, despite intensive therapies. Driven by unique molecular features, these tumors are often therapy-resistant or relapse quickly, and very little is known about why current treatments fail.

ATRT is a rare and aggressive brain tumor that primarily affects children under the age of three and carries a very poor prognosis, with a 5-year survival rate around 30% despite intensive treatment. Defined by specific genetic alterations, ATRTs often recur rapidly, and the reasons behind treatment resistance remain poorly understood.

About The CARE FOR RARE Collaborative

The CARE FOR RARE Collaborative is a bold effort to address the lack of research and funding in these tumor types with the goal to improve survival in these children and includes the following charities: Bibi Fund, The Jonah Finn Foundation, Gold Ribbon Kids Cancer Foundation, Solving Kids’ Cancer, Hope4ATRT Foundation, and the Ty Louis Campbell Foundation

“We urgently need to understand why these tumors are so difficult to treat,” said Cindy Campbell, Co-Founder of Ty Louis Campbell Foundation. “Our collaborative is addressing this need head on, and we won’t stop until we see dramatic improvements in outcomes in these understudied, rare tumors.”

About the Funders

Solving Kids’ Cancer is not just our name, it’s our mission. We help accelerate new clinical trials of next-generation treatments including immunotherapy, targeted agents, and combination therapies through research advocacy, with an understanding of the childhood cancer landscape and current unmet needs to wisely invest in innovative projects.

Hope4ATRT Foundation , a research entity of Out of Zion, Inc., supports families fighting ATRT by providing up-to-date resources and research. Our mission is to be a centralized site where parents can find information to navigate their child’s diagnosis, treatment, and support.

Gold Ribbon Kids Foundation is dedicated to advancing research, advocacy, and support for children and families affected by pediatric cancer. Our mission is to drive innovation in treatments for rare childhood cancers while providing hope and resources to families in need. We partner with leading researchers and organizations worldwide to accelerate cures.

The Bibi Fund for Rare Childhood Cancer Research funds pediatric cancer research with a focus on the rarest and most aggressive childhood brain cancers.

The Jonah Finn Foundation ’s mission is to catalyze groundbreaking preclinical research into ETMR and other rare pediatric brain cancers, fostering hope for a cure by supporting transformative research and encouraging global scientific collaboration.

The Ty Louis Campbell Foundation funds innovative research and clinical trials specifically geared toward the treatment of the most aggressive childhood cancers. Our mission is to help fund the intelligence and technology that will improve long-term survival rates and minimize side-effects for children diagnosed with the deadliest cancers, while helping to care for families when their child is in treatment by providing financial assistance and uplifting experiences.

###

For media inquiries contact Kristi McKay

kristi@solvingkidscancer.org

Lace Up for Kids 2025

Wed, 06 Aug 2025 19:26:30 GMT

Childhood Cancer Awareness Month: Lace Up for Kids 2025

Every year, over 400,000 children worldwide receive the heart-wrenching diagnosis of cancer. This staggering number reminds us of the crucial need for continued awareness, research, and support. This September, during Childhood Cancer Awareness Month , we invite you to join Solving Kids’ Cancer’s Lace Up for Kids program and make a difference. Together, we can shine a light on the realities of childhood cancer and emphasize the importance of life-saving research.

What is Lace Up for Kids?

Lace Up for Kids is more than just a campaign; it’s a movement! Launched in 2017, this initiative has united communities across the globe to raise awareness and funds for pediatric cancer research. By simply swapping your regular shoelaces for our special gold laces, you can show your support and help drive change. The power of this program lies in its simplicity and the heartfelt commitment of individuals like you.

How to Participate in Lace Up for Kids

Getting involved in Lace Up for Kids is fun and easy! Follow these three simple steps to make a big impact:

Step 1: Care

First, register for Lace Up for Kids and create your personal childhood cancer fundraiser page. This is your opportunity to share your story, set your fundraising goal, and show why this cause matters to you. It’s quick and easy, and your dedication helps spread awareness.

Step 2: Wear

Once you’ve registered, keep an eye on your mailbox for your gold shoelaces. When they arrive, swap out your regular laces and go gold for childhood cancer throughout September. Each step you take with those laces on your shoes represents a step towards a brighter future for children with cancer.

Step 3: Share

Now it’s time to spread the word! Share your fundraising page with friends, family, and your social media network. Use the hashtag #CareWearShare to connect with others participating in the campaign. Your voice can inspire others to join the cause and amplify our message.

Lace Up for Kids by the Numbers

Since its inception, Lace Up for Kids has made a remarkable impact thanks to the dedication of supporters like you. Here’s a look at what we’ve achieved together:

250,000 pairs of gold laces worn in all 50 U.S. states.
Over 325 schools, sports teams, and youth organizations involved.
Participants from 20 countries around the world.
Over $450,000 raised for breakthrough treatment options for childhood cancer.

Other Ways to Get Involved in Lace Up for Kids

Looking to take your involvement to the next level? Here are some exciting ways you can make an even bigger impact:

Register as a Team Captain

Invite your friends and family to join your fundraising efforts. Together, you can create a powerful team dedicated to fighting childhood cancer .

Get Your Sports Team Involved

Along with your established fundraiser you can order laces for your entire sports team. Whether you play baseball, basketball, cheer, or football, your team can wear gold laces to show solidarity and raise funds.

Get Your School To Go Gold for Childhood Cancer

Host an informational table at your school to share more about Childhood Cancer Awareness Month and the Lace Up for Kids program. Encourage your classmates to participate and raise awareness together.

Smithtown’s Success Story

Smithtown, NY shines brightly in the fight against childhood cancer. At Nesaquake Middle School, principal Dan and his team transform the school into a sea of gold shoelaces every September. With 500 students proudly wearing gold, the highlight is a “Go Gold” day filled with fun fundraising booths.

Meanwhile, at Accompsett Elementary School, principal Tim leads the “Change Childhood Cancer” campaign, where students bring in spare change, raising over $1,500! The school buzzes with creativity and community spirit as students wear their gold laces in unique ways – in their hair, as bracelets, and even as creative shoelace art on their backpacks.

“Smithtown is a very generous community. Our Lace Up for Kids fundraiser empowers our young students to be philanthropic and teaches them the important lesson that you can achieve great things by working together. Whether kids bring in a handful of pennies or a twenty-dollar bill they are able to participate in the fight against childhood cancer.”

-Timothy Hellmuth, Principal, Accompsett Elementary School

Unite your school or classroom like Smithtown, NY! Join the Lace Up for Kids campaign this September. Register, wear your gold shoelaces, and help us fund critical cancer research.

FAQs About Lace Up for Kids

What is Lace Up for Kids?
Lace Up for Kids is a fundraising and awareness campaign by Solving Kids’ Cancer. Participants wear gold shoelaces in September to support childhood cancer research. View our Campaign Toolkit for more information.

How can I get involved?
You can register, fundraise, wear gold laces, and share your efforts on social media.

Where do the funds go?
Funds raised support breakthrough treatment options for pediatric cancer.

Who can participate in Lace Up for Kids?
Anyone can participate! We encourage individuals, families, schools, sports teams, and community organizations to join the cause.

How do I register for Lace Up for Kids?
You can register on our website by filling out a simple form. Once registered, you will receive a fundraising page to share with your network.

When will I receive my gold shoelaces?
After registering, you will receive your gold shoelaces in the mail. Delivery times may vary, so please allow a week for shipping.

What are some fundraising ideas?
Fundraising ideas include hosting a bake sale, organizing a charity run or walk, setting up a donation drive, and using social media to spread the word and gather support.

How do I share my fundraising page?
You can share your fundraising page via email, social media, and word of mouth. Use the hashtag #CareWearShare to join the online conversation.

How do I track my fundraising progress?
Your fundraising page will have a built-in tracker to monitor donations and progress towards your goal. You will receive email notifications as contributions are made.

Are donations tax-deductible?
Yes, donations to Solving Kids’ Cancer are tax-deductible to the extent permitted by law. Donors will receive a receipt for their contribution.

Can I donate without participating in the Lace Up for Kids program?
Absolutely! You can make a direct donation on our website to support childhood cancer research.

What should I do if I have not received my laces?
If you haven’t received your gold shoelaces within two weeks of registering, please contact heroes@solvingkidscancer.org for assistance.

How can my school or sports team get involved?
Your school or sports team can participate by registering as a group and organizing fundraising events. Hosting an awareness event or sharing information about childhood cancer are also great ways to get involved.

Ready to Join Us?

This September, let’s make a GOLD statement for Childhood Cancer Awareness Month. Show the world our dedication to supporting childhood cancer patients and their families, and our commitment to finding new and innovative treatment options — because every kid deserves to grow up.

Give the Gift of Hope

kristi@solvingkidscancer.org (Kristi McKay) — Mon, 02 Dec 2024 00:21:56 GMT

Ways to Give Back During the Holidays

Holiday Fundraiser Ideas to Support Kids with Cancer

For most, the holidays mean joy, togetherness, and warm memories by the fire. But for families facing pediatric cancer, this season can feel anything but magical. A cancer diagnosis doesn’t pause for the holidays. Families balance treatment plans, hospital visits, and everyday life while holiday traditions take a backseat. At Solving Kids’ Cancer, every child deserves a future filled with joy, laughter, and holiday cheer. That’s why we’re laser-focused on finding breakthroughs and cures for the most aggressive childhood cancers.

This season, YOU can help bring the magic of hope back to these families. Whether planning a holiday fundraiser or looking for fundraising ideas for charities, every action—big or small—makes an impact. Here’s how you can be part of the mission:

1. Be a Voice of Hope

Your voice matters. Shouting it from the rooftops is optional, but sharing is essential! By joining our online community, you’re helping amplify the urgency of our mission. Share posts, spread awareness, and invite others to join the fight. Every share can lead to another heart moved to action.

�� Post this on your feed:

Every child deserves a chance to grow up! I’m giving back this holiday season by supporting @SolvingKidsCancer, a non-profit organization dedicated to life-saving research for pediatric cancer. Together, we can bring hope to kids facing cancer. → solvingkidscancer.org

Did You Know?

Sharing a post on social media can reach over 300 people on average — that’s 300 potential supporters who might not have known about the urgent need for pediatric cancer research!

2. Start a Fundraiser in 5 Minutes

Got a fun idea? A knack for baking? A flair for running or hosting events? Great — because every creative spark can fuel hope! Starting a fundraiser is so simple with our platform. In just a few clicks, you can raise funds to support life-saving research for kids who need it most.

Inspire Others

Brandon Perna, creator of That’s Good Sports, turned his passion for sports into hope for kids battling cancer.

“I love raising money for SKC because I know every dollar makes a huge impact towards helping one of the worst scenarios any parent can imagine. Once they connected their charity through YouTube, it became incredibly easy for me to create a fundraiser on my channel, and I plan on doing more throughout the year… I can’t think of many things more important than the work they’re doing.”

�� Tip: Make your holiday fundraiser personal. Tell your audience why you care — it could inspire them to join you!

3. Double or Triple Your Donation

Did you know your employer might be Santa in disguise? Many companies match employee donations, turning your $50 into $100 — or more! It’s one of the easiest ways to maximize your impact, and it only takes a few minutes to check with your HR department.

Why It Matters

Matching programs help stretch resources further, ensuring that more research is funded and more children have access to potentially life-saving treatments.

4. Make Your Birthday a Celebration of Hope

Start next year off right — by giving back! Instead of birthday presents, ask your friends and family to donate to Solving Kids’ Cancer. Their generosity will help fund cutting-edge treatments for kids battling cancer. One meaningful day can make an entire year brighter for these families.

Did You Know?

Hosting a birthday fundraiser on platforms like Facebook or Instagram is one of the fastest ways to rally support. It’s also a great way to find fundraising ideas for charity that resonate with your network.

5. Get Creative with Crafting for a Cause

Calling all creators! Whether it’s handmade ornaments, holiday cards, or knitted scarves, you can turn your talent into life-saving support. Plus, crafting together is a great way to involve the kids and teach them about giving back.

Audrey’s Angels

Audrey was diagnosed with high-risk neuroblastoma when she was just 5 years old. At 11, she began creating beautiful angel ornaments out of soda cans to raise money for childhood cancer nonprofits like Solving Kids’ Cancer.

“Making the angels is an amazing way for me to give back to the community even as a student. I want to support those who have been in the same situation as I have and hope for a better future for children with cancer.”

�� Creative Idea: Turn your crafting session into a holiday fundraiser! Invite friends to join and donate the proceeds to Solving Kids’ Cancer. Fun + fundraising = double the joy!

6. Give a Gift in Memory of a Child

Looking for a meaningful gift this holiday season? Give in memory of a child who has lost their battle or in honor of a child still fighting. Your gift will fund research for safer, more effective treatments and bring hope to families facing the unimaginable.

A Mother’s Tribute

Lara W. honors her son Hans, forever 8, by giving back.

“We’ve been through clinical trials ourselves, and we know how vital they are. Giving back helps ensure other families have the same opportunity like us. Charities like Solving Kids’ Cancer fill critical funding gaps that no one else does.”

�� A Special Touch: Send a holiday card letting someone know you’ve donated in their honor—it’s a heartfelt way to celebrate the season.

Make Hope a Holiday Tradition

Whether you’re hosting a holiday fundraiser, sharing on social media, or making a gift in memory of a loved one, your actions this holiday season bring us closer to cures. Together, we can create a world where children grow up healthy, happy, and cancer-free.

Thank you for joining us in this mission of hope. Let’s make this season truly magical.

Ahana’s Story of Strength

duda@neonone.com — Wed, 20 Nov 2024 21:43:44 GMT

Ahana’s Story of Strength with High-Risk Neuroblastoma

Every day, over 1,000 children worldwide are diagnosed with cancer,1 and for many families, that diagnosis means facing an uncertain future. At just 20 months old, Ahana was diagnosed with a rare and aggressive cancer that had already spread through her small body. Her family’s search for life-saving childhood cancer treatments led them from South Africa to Spain and possibly toward a clinical trial in New York. Ahana’s journey shows the importance of supporting organizations like Solving Kids’ Cancer, which works to find, fund, and advocate for advanced treatments that give hope to families fighting against tough-to-treat rare pediatric cancers.

A Devastating Diagnosis and a Family’s Determination

It all started when Ahana’s family first noticed a small lump on the back of their fun and energetic little girl. They took her to the doctor, hoping for a simple explanation.

Instead, they were told that a large tumor was pressing on her heart, lungs, and spinal cord, affecting her breathing and partially paralyzing her vocal cords. Her father, Aveen, recalls the moment clearly: “We were told that she had a large malignant tumor measuring 15cm in diameter. We were shattered.”

The diagnosis was stage 4 high-risk neuroblastoma , a rare pediatric cancer that affects around 700-800 children each year in the United States alone.2 Neuroblastoma is especially aggressive and difficult to treat, with only about a 50% survival rate for advanced cases because of the high risk of relapse, even after remission.3 Knowing Ahana would need the best possible childhood cancer treatment, her family made the difficult decision to relocate from South Africa to Spain, leaving behind their home and support network in hopes of giving her a better chance.4

A Setback in Spain: The Struggles of Childhood Cancer Treatment

When they arrived in Barcelona, Ahana’s medical team at Sant Joan de Déu Hospital (SJD) had hoped to remove her tumor through surgery. But within two weeks, new scans showed that the tumor had doubled in size, building up fluid in her lungs and making surgery impossible. Ahana’s doctors quickly turned to a specialized chemotherapy plan to control the cancer’s aggressive growth, and she began her first round, which included a targeted drug called Dasatinib.

However, just hours after starting treatment, Ahana’s body reacted severely. She lost consciousness, her oxygen levels dropped, and she was rushed to intensive care.

Her mother, Avanya, recalls, “Life support was the only option.” The chemotherapy drug had caused heart damage, and doctors feared she had only hours left. Miraculously, Ahana’s body began to stabilize six hours later, and over the next few days, her heart function gradually improved.

Ahana’s struggle with the drug Dasatinib also shows the urgent need for treatments made just for children. Nearly two-thirds of childhood cancer survivors suffer long-term side effects from treatments designed for adults, which can harm their growing bodies.5 Child-focused cancer treatments are crucial to give young patients a healthier future without added health complications.

Ahana’s incredible recovery caught the attention of doctors from St. Jude Children’s Research Hospital in the United States. While visiting SJD, they asked if they could study her genetic data, hoping her case could help other children facing similar challenges. Her strength inspired everyone, giving her family renewed hope for the road ahead.

Progress After Surgery and a Race Against Time

With additional cycles of chemotherapy, coupled with the drug Lorlatinib to address a mutation they identified, Ahana’s tumor shrank by 50%, making surgery possible. A skilled team of doctors then performed a six-hour operation, successfully removing over 90% of the tumor. Showing incredible resilience, Ahana spent just one day in intensive care before going home four days later.

But even with this progress, Ahana’s journey is far from over. Neuroblastoma has one of the highest relapse rates of all childhood cancers . Even when remission is achieved, the cancer often comes back, leaving children with advanced cases, like Ahana’s, with only a 1 in 5 chance of surviving five years post-diagnosis, even with aggressive childhood cancer treatment.6 To reduce this risk, Ahana’s parents began researching options and found hope in a clinical trial at Memorial Sloan Kettering Cancer Center (MSK) in New York.7 This trial, which is the only one of its kind, is testing a cancer vaccine to prevent neuroblastoma from returning — a critical need for children like Ahana.

“Right now, this is our last and only option as it gives us hope for Ahana’s best chance of survival,” Avanya explains. “Time is of the essence as Ahana’s body is being ravaged by the progressing cancer.” Her family is now urgently raising funds to get her into the MSK trial, hoping to provide her with the most promising path to a full recovery.

The Power of Community Support

Ahana’s journey with high-risk neuroblastoma would not be possible without the support of a compassionate community. Friends, family, and even strangers have come together through GoFundMe and other platforms to help cover the high costs of treatment and travel. The Bluff Athletics Club in South Africa organized a 5km walk/run for Ahana, with over 400 people gathering to show their support and raise funds. “We are endlessly grateful for everyone who has helped us,” Avanya shared, deeply moved by the generosity that has kept them going.

Ahana’s story highlights how essential community support is for families facing childhood cancer. Childhood cancer statistics worldwide show that families with strong support networks are more likely to access the care they need, especially for rare and aggressive cancers. Solving Kids’ Cancer is dedicated to helping these families by funding research, connecting them with vital treatments, and advocating for solutions that give children like Ahana the best chance to fight.

The Mission of Solving Kids’ Cancer: Putting Kids First

At Solving Kids’ Cancer, our focus is simple: to make sure children with rare pediatric cancers get the attention and care they need. In a world where many needs compete, kids with rare cancers are sometimes left behind in the search for new treatments. We’re here to change that by funding important research and pushing for better treatments, giving real hope to families who need it most.

But our work isn’t just about funding studies. It’s about making sure children get faster access to new therapies, especially for tough cancers like high-risk neuroblastoma. This means helping kids receive treatments sooner, combating disparities that prevent access due to geography, and improving therapies like immunotherapy so they work better for young patients.

When you support Solving Kids’ Cancer, you’re helping families like Ahana’s gain access to life-saving clinical trials and treatments that can save lives. Together, we can make sure that every child has the chance to grow up healthy and strong.

Join Us in the Fight Against Childhood Cancer

Today, you can be part of Ahana’s story and support children around the globe who face similar battles. Every donation to Solving Kids’ Cancer fuels hope, funding the research and treatments that bring us closer to life-saving breakthroughs — because every kid deserves to grow up.

Sources

1 World Health Organization: Childhood Cancer – International Childhood Cancer 2024: Reducing the Survival Gap
https://www.emro.who.int/media/news/international-childhood-cancer-day-2024-reducing-the-survival-gap.html

2 National Library of Medicine – Treatment and Survival of Childhood Neuroblastoma: Evidence from a Population-Based Study in the United States
https://pmc.ncbi.nlm.nih.gov/articles/PMC6764456/

3 MedicineNet – What Is the Life Expectancy of a Child with Neuroblastoma?
https://www.medicinenet.com/life_expectancy_of_a_child_with_neuroblastoma/article.htm

4 Southlands Sun News – Little Cancer Fighter Continues to Defy the Odds
https://www.citizen.co.za/southlands-sun/news-headlines/2024/10/16/little-cancer-fighter-continues-to-defy-the-odds/

5 National Library of Medicine – Late Effects of Childhood Cancer
https://www.ncbi.nlm.nih.gov/books/NBK221735/

6 National Library of Medicine – PCR-based amplification of circulating RNAs as prognostic and predictive biomarkers – Focus on neuroblastoma
https://pmc.ncbi.nlm.nih.gov/articles/PMC5575362/

7 Southlands Sun News – Help Bluff toddler receive international lifesaving cancer treatment
https://www.citizen.co.za/southlands-sun/news-headlines/local-news/2023/12/19/help-bluff-toddler-receive-international-lifesaving-cancer-treatment/

2024 Year-in-Review

Mon, 11 Nov 2024 02:51:32 GMT

Advancing Childhood Cancer Research: SKC’s 2024 Milestones

Dear Friends and Supporters,

As we look back on 2024, I want to extend my heartfelt thanks to every donor, volunteer, and partner who has stood with us. Because of you, Solving Kids’ Cancer has been able to push forward with groundbreaking research and open new doors to treatments for children facing the toughest cancers. Your support fuels our work and brings hope to families in their most difficult moments.

At Solving Kids’ Cancer, our mission goes beyond research — it’s about making sure children with cancer are at the forefront of every breakthrough. When so much competes for attention in the medical field, kids with rare cancers can sometimes be overlooked. We’re here to make sure they’re not left behind, focusing on research that leads to real solutions kids can access sooner. This year, we’ve seen exciting progress in immunotherapy, targeted treatments, and personalized care, bringing us closer to a future where more children can overcome cancer.

New Cancer Breakthroughs in Research

This year, Solving Kids’ Cancer made significant strides in childhood cancer research. Here are some highlights:

Advancing Brain Tumor Research: With the help of our partners, we’ve made strides in treating high-risk brain tumors . Quarterly conferences brought top experts together, setting the stage for new clinical trials and treatments.
Solving Indolent Neuroblastoma: This project focuses on developing diagnostic tools and new childhood cancer treatments for slow-growing neuroblastoma . This year, we created a test for ALT biomarkers, established nine patient-derived neuroblastoma models, and identified PF-06821497 as a promising drug to enhance outcomes.
New Steps in Immunotherapy: We are working to make immunotherapy a stronger option for children with hard-to-treat cancers like medulloblastoma. This year’s research is expected to lead to clinical trials in 2025, moving these treatments closer to young patients.

Leadership in Collaboration and Advocacy

Collaboration is key at Solving Kids’ Cancer. We teamed up with global partners and made sure children’s needs were at the center of our efforts:

Pediatric Brain Tumor Research Network (PBTRN): Partnering with Columbia University, we launched this network to connect researchers from around the world, aiming to speed up brain tumor treatments for children .
Advocating for High-Risk Brain Tumor Treatments: SKC joined the Pediatric Strategy Forum to push for new therapies for diffuse midline gliomas (DMG), advocating against placebo trials and for innovative childhood cancer treatments targeting SMARCA4 and GD2.
Shaping Clinical Trial Design: Our advocacy led the Children’s Oncology Group (COG) to make a landmark decision for trial ANBL2431, which will compare chemo-immunotherapy1 with a reduced transplant regimen. This decision highlights the growing role of patient advocacy in research and treatment protocols.

Our Research in the Spotlight

Solving Kids’ Cancer’s research contributions reached new heights this year through key publications and media features

FDA Approval of IWILFIN: After 15 years of effort, we celebrated the FDA’s approval of IWILFIN, a neuroblastoma maintenance therapy. This approval shows the power of long-term advocacy and partnership.
Innovative GD2BATs Immunotherapy Trial: We shared results from a clinical trial using GD2BATs2 — an immunotherapy that equips T cells with antibodies to target cancer cells in neuroblastoma and osteosarcoma . The study showed this approach is safe and effective, bringing new hope to families facing these tough cancers.
Influencing Future Clinical Trials: Our published paper, “To transplant, or not to transplant? That is the question,”3 offered vital insights on using autologous stem cell transplant (ASCT) in high-risk neuroblastoma. By examining evidence and parent views, we encouraged new patient-centered approaches.

Events That Brought Us Together

From fundraising events to community gatherings, we connected with our community throughout the year:

Comedy Fights Kids’ Cancer: Hosted by comedian Seth Herzog, this event gave our supporters a night of laughter while raising vital funds for our work.
Summer Luncheon in the Hamptons: Our eighth annual luncheon gathered advocates and donors to celebrate our progress and rally even more backing for research.
That’s Good Sports Fundraiser: This live-streamed fundraising event during the Broncos vs. Saints game brought sports fans together in a fun way to fuel childhood cancer research.

Thanks to the incredible commitment of our community, these events reinforced our mission to build a world where no child faces cancer alone.

Keep Advancing Childhood Cancer Research with Us

Each child battling cancer deserves a real chance at a cure, and every new discovery brings us one step closer. Your support helps launch new treatments, brings together experts to find solutions, and offers hope to families facing the toughest challenges.

This holiday season, your gift can directly impact these children and families. There’s still so much more to be done, and every dollar will help drive new cancer breakthroughs forward, advancing life-saving work that gives kids the chance they deserve.

Thank you for being part of this journey. Your support is making a difference, one child at a time.

With deep gratitude,

Scott Kennedy

Executive Director & Co-Founder

Solving Kids’ Cancer

Sources

National Library of Medicine – Chemotherapy: A New Trend in Cancer Treatment https://pmc.ncbi.nlm.nih.gov/articles/PMC10252089/
National Library of Medicine – Targeting refractory/recurrent neuroblastoma and osteosarcoma with anti-CD3xanti-GD2 bispecific antibody armed T cells https://pubmed.ncbi.nlm.nih.gov/38519053/
National Library of Medicine – To transplant, or not to transplant? That is the question. A patient advocate evaluation of autologous stem cell transplant in neuroblastoma https://pubmed.ncbi.nlm.nih.gov/35373890/

2024 Lace Up for Kids Recap

Tue, 01 Oct 2024 14:00:21 GMT

Lace Up for Kids: Your Impact on Childhood Cancer Research

At Solving Kids’ Cancer, our mission has always been driven by hope — hope for better treatments, hope for breakthroughs, and most importantly, hope for every child fighting cancer. This year’s Lace Up for Kids campaign was nothing short of inspiring. Together, we’ve raised over $264,000 across the entire campaign, funding innovative childhood cancer research and providing more treatment options for children in need.

From coast to coast, nearly 4,000 participants have stepped up to lace up their gold shoelaces and make a difference. Whether it was through schools, sports teams, or community groups, the show of support has been overwhelming throughout the years. Over 7,823 donations have been made to accelerate new treatments, and the hashtag #CareWearShare has been used 13,864 times, spreading the message far and wide!

Your Participation Means the World

To every student, teacher, athlete, parent, and friend who participated in this year’s Lace Up for Kids, we want you to know how deeply grateful we are for your help in raising critical children’s cancer research funds. Whether you walked miles, ran races, or simply shared the cause with your network, each act of kindness had a ripple effect.

With 212,500 gold shoelaces distributed, this childhood cancer fundraiser’s message of hope has reached far and wide. Some schools have organized entire days dedicated to childhood cancer awareness, with classrooms buzzing with excitement and determination. Many participants have told us how they felt connected to something larger than themselves, knowing that they were raising funds for children in the fight of their lives.

Stories That Touched Our Hearts

Throughout this campaign, we were fortunate to hear the stories behind the participation. Parents told us about lacing up in honor of their children who are fighting cancer. Teachers shared about students who learned valuable lessons on compassion and empathy by taking part in Lace Up for Kids. These moments remind us of why we continue this important work.

One story that stands out is from Erin Martin, a 14-year-old student from San Antonio, Texas, who has been actively raising awareness for childhood cancer in 2021. Since starting her efforts, Erin and her friends have shared their passion for helping children with their classmates and community, earning a plaque that now proudly hangs in their school lobby.

More Than Just Gold Shoelaces

What makes Lace Up for Kids so special is that it’s about more than just raising money—it’s about raising awareness and standing in solidarity with families facing unimaginable challenges. Every gold lace worn is a symbol of hope. When we go gold for childhood cancer, we remind the world that cancer isn’t something we can ignore; it’s a battle we’re determined to win.

The Smithtown Schools, for example, have consistently gone above and beyond. Over the years, students and staff have organized school-wide cancer awareness days and fundraising challenges, encouraging students to lace up their gold shoelaces and show support for pediatric cancer patients. Their efforts have helped their community foster a deeper understanding of the fight children with cancer face every day.

What Your Support Achieves

Because of you, the funds raised this year will go directly toward advancing life-saving research and treatments for the most aggressive childhood cancers. Your contributions support projects like immunotherapy research1 and clinical trials for less toxic therapies, giving children hope for recovery without the harsh side effects of traditional treatments.

One of our key initiatives is funding the first-ever clinical trials for ETMR (Embryonal Tumor with Multilayered Rosettes), a rare and deadly pediatric brain tumor. Thanks to your support, we’re not only providing access to cutting-edge trials but also driving the development of new treatment protocols that could transform pediatric cancer care.

Support Childhood Cancer Research Year-Round

Even though Lace Up for Kids is over, there are many ways you can go gold for childhood cancer throughout the year. Here are a few simple, practical ways to stay involved:

Monthly Giving: Set up a recurring donation to make a consistent impact. Even small monthly contributions add up over time and help sustain critical research projects.
Host a Childhood Cancer Fundraiser: Whether it’s a bake sale, garage sale, or online donation drive, you can raise funds in your community to support groundbreaking research for kids with cancer.
Spread Awareness: Share stories from Solving Kids’ Cancer and the impact of ongoing research on your social media. Raising awareness is just as powerful as fundraising and helps spread the message.
Employer Matching Gifts: Check if your employer offers a matching gift program. This simple step can double or even triple the impact of your donation.
Volunteer Your Time: Explore opportunities to get involved locally by volunteering at awareness events or helping to spread the word about childhood cancer research.
Stay Informed: Sign up for our newsletter to keep up to date with the latest in childhood cancer research and learn about new ways to support children and families battling cancer.

By staying active and engaged, you’re helping to fuel research that gives children hope for a brighter, healthier future.

Missed Laces? You Can Still Make an Impact!

If you couldn’t join us for Lace Up for Kids, there’s still a way to be part of the mission. Your donation supports groundbreaking childhood cancer research and gives hope to children and their families. Every contribution, big or small, moves us closer to a future without childhood cancer — because every kid deserves to grow up.

Source:

1 Immunotherapy of Neuroblastoma: Facts and Hopes – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9344822/

Stories of Impact: Erin Martin

Mon, 02 Sep 2024 09:21:37 GMT

Gold Laces for Childhood Cancer Awareness Month: Erin’s Story

Erin Martin’s journey began with a simple pair of gold shoelaces, but it has grown into a powerful mission to make a difference in the fight against childhood cancer. At just 14 years old, Erin has dedicated herself to raising awareness and funds for pediatric cancer research through Solving Kids’ Cancer’s annual Lace Up for Kids campaign.

Why is her work so crucial? Because every day, 47 children in the United States are diagnosed with cancer,1 and despite advances in research, cancer remains the leading cause of death by disease for children.1 Erin’s mission is to change that, one pair of gold shoelaces at a time.

And she’s not alone. Through the Lace Up for Kids campaign, 150,000 pairs of gold laces have been worn in all 50 U.S. states, and over 250 schools, sports teams, and youth organizations have joined the cause. This global movement has reached participants in 20 countries and raised over $250,000 to support breakthrough treatment options for childhood cancer.

To inspire others and learn firsthand what drives Erin to keep going, we spoke with her about her journey, the challenges she faced, and the impact she’s determined to make.

How It All Started

Three years ago, Erin was introduced to the Lace Up for Kids campaign, and she was instantly hooked. What began as a simple program activity soon became a deeply personal mission. “I first got involved in Lace Up for Kids through a program, but even after it ended, I couldn’t stop,” Erin shared. “Not many kids my age are aware of what’s going on around them, and I wanted to change that.”

Every September, during Childhood Cancer Awareness Month , Erin would hand out the campaign’s special gold shoelaces to her classmates, encouraging them to wear the laces and show their support. “The most rewarding part of this journey is sharing it with my friends,” Erin said with a smile. “We even made my middle school an official ambassador for the campaign — we have a plaque in the lobby now.”

The Mission Behind Lace Up for Kids

Lace Up for Kids is more than just a childhood cancer fundraiser — it’s a movement that unites communities in support of children battling cancer. The gold shoelaces symbolize the gold ribbon, the international sign of Childhood Cancer Awareness. By wearing these laces, you’re making a visible statement of care and helping to advance lifesaving research.

Solving Kids’ Cancer focuses on the toughest childhood cancers—those that are the most difficult to treat and have the fewest options. SKC’s mission is to discover, fund, and advocate for next-generation treatments that can offer hope where it’s needed most. Campaigns like Lace Up for Kids are a big part of this mission, bringing people together to make a real difference. For Erin, being part of this campaign means joining something bigger—something that can change the future for kids fighting cancer.

Juggling School, Hobbies, and Advocacy

Erin’s life is busy — like most teens her age — but she’s found a way to balance everything. From staying on top of her schoolwork and enjoying pageantry to spending time with her friends, Erin manages it all while remaining committed to her advocacy work. She’s motivated by a mantra she holds close: “One day or day one, you decide” a quote from Paulo Coelho. For Erin, it’s a reminder that every day is a chance to start something new and make progress, whether it’s in her studies or her mission to raise awareness for childhood cancer.

“I use a dry-erase board to keep track of everything,” Erin explained. “Getting my schoolwork done sooner gives me more time after school to volunteer and work on projects like Lace Up for Kids.” Her disciplined approach, guided by her mantra, helps her manage her commitments while making a real difference in the fight against childhood cancer.

Overcoming Challenges and Staying Motivated

Even though Erin is a natural leader, she admits that advocating for childhood cancer isn’t always easy. “I get nervous, especially when I’m asking people for support,” Erin confessed. “But I remind myself that the worst thing they can say is ‘no,’ and that’s okay.”

Her family and friends play a huge role in her success, helping her pass out shoelaces and promote the cause. “They’re my biggest supporters in everything I do,” Erin said gratefully. She’s seen the impact of these small gestures firsthand. “Wearing these laces is a small thing, but it means a lot,” she shared. “It’s a way to show kids with cancer that they aren’t alone in their fight.”

Tips from Erin: How to Get Involved and Make a Difference

Erin’s journey in childhood cancer awareness has been nothing short of inspiring. Here’s her personal advice for making a real impact.

Start Small: You don’t have to do something huge right away. Start by talking to your friends and family about the cause and see how they can help.
Be Bold: Don’t be afraid to ask for support. It can be nerve-wracking, but remember, the worst thing that can happen is someone says ‘no.’
Stay Organized: Find a system that works for you, such as a planner, an app, or a simple to-do list. Staying organized helps balance your commitments and ensures you can dedicate time to what matters most.
Get Your Community Involved: Encourage others in your community — at school, work, or within local organizations — to join the cause. Building a supportive network amplifies your impact and brings more people together for the mission.
Keep Going: Even if it gets tough, don’t give up. Remember why you started and keep pushing forward.

Looking Ahead: Erin’s Vision for the Future

Erin isn’t stopping here — her ambitions are growing just as quickly as her impact. She envisions organizing a grand gala, a night where people come together, dressed to the nines, united by the common goal of raising substantial funds for childhood cancer research. For Erin, this event wouldn’t just be another childhood cancer fundraiser; it would be a symbol of hope and a testament to the strength of communities rallying together.

But Erin’s vision extends beyond glamorous events. She’s determined to make a lasting impact by influencing legislation and advocating for increased government funding for pediatric cancer research. “There are kids like me and even younger who are going through cancer,” she reflected, understanding the urgency of her mission. Her goal is to secure more funding through legislative action so that fewer families have to rely on grassroots fundraising efforts. “If I can do something, anything, to help, then I’ll do it,” she adds, showing the resolve that drives her mission.

Join Erin and Lace Up for Kids

Like Erin, who started with a simple pair of gold laces and a big heart, you too can make a difference in the lives of children battling cancer. This September during Childhood Cancer Awareness Month, join Lace Up for Kids to take a stand and help ensure that no child has to face cancer alone — because every kid deserves to grow up .

If you can’t join the campaign, consider making a donation to cancer research to support the ongoing fight against childhood cancer.